Cyclotriazadisulfonamide hydrochloride
CAS No. 392287-03-5
Cyclotriazadisulfonamide hydrochloride ( Cyclotriazadisulfonamide hydrochloride (182316-44-5 Free base) )
Catalog No. M28215 CAS No. 392287-03-5
Cyclotriazadisulfonamide hydrochloride is a selective inhibitor of CD4-targeted HIV entry and inhibits the co-translational translocation of human CD4 into the ER lumen in a signal peptide-dependent way.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 393 | Get Quote |
|
10MG | 590 | Get Quote |
|
25MG | 1060 | Get Quote |
|
50MG | 1591 | Get Quote |
|
100MG | 2387 | Get Quote |
|
200MG | 3580 | Get Quote |
|
500MG | Get Quote | Get Quote |
|
1G | Get Quote | Get Quote |
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Biological Information
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Product NameCyclotriazadisulfonamide hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionCyclotriazadisulfonamide hydrochloride is a selective inhibitor of CD4-targeted HIV entry and inhibits the co-translational translocation of human CD4 into the ER lumen in a signal peptide-dependent way.
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DescriptionCyclotriazadisulfonamide hydrochloride is a selective inhibitor of CD4-targeted HIV entry and inhibits the co-translational translocation of human CD4 into the ER lumen in a signal peptide-dependent way.(In Vitro):Cyclotriazadisulfonamide hydrochloride exhibits an EC50 of 0.4 μg/mL for CD4 in MO-DC cells. Cyclotriazadisulfonamide hydrochloride (10 μg/mL) results in 83% downregulation of cell surface CD4.Cyclotriazadisulfonamide hydrochloride prevents MT-4 cells from HIV-1 and SIV infection with EC50s of 0.7 and 1.2 g/ml, respectively. Cyclotriazadisulfonamide hydrochloride significantly decreases the amount of cell surface CD4 -the main receptor for HIV -without altering the expression of any other cellular receptor examined so far.
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SynonymsCyclotriazadisulfonamide hydrochloride (182316-44-5 Free base)
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PathwayMicrobiology/Virology
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TargetHIV
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number392287-03-5
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Formula Weight618.3
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Molecular FormulaC31H40ClN3O4S2
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Purity>98% (HPLC)
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Solubility——
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SMILESCC1=CC=C(S(=O)(N(CCCN(CC2=CC=CC=C2)CCCN(S(C3=CC=C(C=C3)C)(=O)=O)C4)CC4=C)=O)C=C1.Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Elzainy TA, Ali TH. NAD deamidation "a new reaction" by an enzyme from Aspergillus terreus DSM 826. Antonie Van Leeuwenhoek. 2005 Feb;87(2):119-29.
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