Cyclotriazadisulfonamide hydrochloride( Cyclotriazadisulfonamide hydrochloride (182316-44-5 Free base) )

Catalog No. M28215 CAS No. 392287-03-5

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

Cyclotriazadisulfonamide hydrochloride
Note

Research use only, not for human use.
Brief Description

Cyclotriazadisulfonamide hydrochloride is a selective inhibitor of CD4-targeted HIV entry and inhibits the co-translational translocation of human CD4 into the ER lumen in a signal peptide-dependent way.
Description

Cyclotriazadisulfonamide hydrochloride is a selective inhibitor of CD4-targeted HIV entry and inhibits the co-translational translocation of human CD4 into the ER lumen in a signal peptide-dependent way.(In Vitro):Cyclotriazadisulfonamide hydrochloride exhibits an EC50 of 0.4 μg/mL for CD4 in MO-DC cells. Cyclotriazadisulfonamide hydrochloride (10 μg/mL) results in 83% downregulation of cell surface CD4.Cyclotriazadisulfonamide hydrochloride prevents MT-4 cells from HIV-1 and SIV infection with EC50s of 0.7 and 1.2 g/ml, respectively. Cyclotriazadisulfonamide hydrochloride significantly decreases the amount of cell surface CD4 -the main receptor for HIV -without altering the expression of any other cellular receptor examined so far.
In Vitro

——
In Vivo

——
Synonyms

Cyclotriazadisulfonamide hydrochloride (182316-44-5 Free base)
Pathway

Microbiology/Virology
Target

HIV
Recptor

——
Research Area

——
Indication

——

CAS Number

392287-03-5
Formula Weight

618.25
Molecular Formula

C31H40ClN3O4S2
Purity

>98% (HPLC)
Solubility

——
SMILES

CC1=CC=C(S(=O)(N(CCCN(CC2=CC=CC=C2)CCCN(S(C3=CC=C(C=C3)C)(=O)=O)C4)CC4=C)=O)C=C1.Cl
Chemical Name

——

1.Elzainy TA, Ali TH. NAD deamidation "a new reaction" by an enzyme from Aspergillus terreus DSM 826. Antonie Van Leeuwenhoek. 2005 Feb;87(2):119-29.

Calculator

molnova catalog