Cyclotriazadisulfonamide hydrochloride( Cyclotriazadisulfonamide hydrochloride (182316-44-5 Free base) )

Catalog No. M28215 CAS No. 392287-03-5

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Product Name

Cyclotriazadisulfonamide hydrochloride
Note

Research use only, not for human use.
Brief Description

Cyclotriazadisulfonamide hydrochloride is a selective inhibitor of CD4-targeted HIV entry and inhibits the co-translational translocation of human CD4 into the ER lumen in a signal peptide-dependent way.
Description

Cyclotriazadisulfonamide hydrochloride is a selective inhibitor of CD4-targeted HIV entry and inhibits the co-translational translocation of human CD4 into the ER lumen in a signal peptide-dependent way.(In Vitro):Cyclotriazadisulfonamide hydrochloride exhibits an EC50 of 0.4 μg/mL for CD4 in MO-DC cells. Cyclotriazadisulfonamide hydrochloride (10 μg/mL) results in 83% downregulation of cell surface CD4.Cyclotriazadisulfonamide hydrochloride prevents MT-4 cells from HIV-1 and SIV infection with EC50s of 0.7 and 1.2 g/ml, respectively. Cyclotriazadisulfonamide hydrochloride significantly decreases the amount of cell surface CD4 -the main receptor for HIV -without altering the expression of any other cellular receptor examined so far.
In Vitro

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In Vivo

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Synonyms

Cyclotriazadisulfonamide hydrochloride (182316-44-5 Free base)
Pathway

Microbiology/Virology
Target

HIV
Recptor

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Research Area

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Indication

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CAS Number

392287-03-5
Formula Weight

618.25
Molecular Formula

C31H40ClN3O4S2
Purity

>98% (HPLC)
Solubility

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SMILES

CC1=CC=C(S(=O)(N(CCCN(CC2=CC=CC=C2)CCCN(S(C3=CC=C(C=C3)C)(=O)=O)C4)CC4=C)=O)C=C1.Cl
Chemical Name

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1.Elzainy TA, Ali TH. NAD deamidation "a new reaction" by an enzyme from Aspergillus terreus DSM 826. Antonie Van Leeuwenhoek. 2005 Feb;87(2):119-29.

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